Title |
Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study
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Published in |
BMC Immunology, February 2013
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DOI | 10.1186/1471-2172-14-8 |
Pubmed ID | |
Authors |
Axel Nierhaus, Stefanie Klatte, Jo Linssen, Nina M Eismann, Dominic Wichmann, Jörg Hedke, Stephan A Braune, Stefan Kluge |
Abstract |
Sepsis is a serious disease condition and a major cause of intensive care unit (ICU) admission. Its diagnosis in critically ill patients is complicated. To diagnose an infection rapidly, and to accurately differentiate systemic inflammatory response syndrome (SIRS) from sepsis, is challenging yet early diagnosis is vital for early induction of an appropriate therapy. The aim of this study was to evaluate whether the immature granulocyte (IG) count is a useful early diagnostic marker of sepsis compared to other markers. Therefore, a total of 70 consecutive surgical intensive care patients were assessed. IGs were measured from whole blood samples using an automated analyzer. C-reactive protein (CRP), lipopolysaccharide binding protein (LBP) and interleukin-6 (IL-6) concentrations were also determined. The observation period was a maximum of 21 days and ended with the patients' discharge from ICU or death. Receiver operating characteristic (ROC) analyses were conducted and area under the curve (AUC) was calculated to determine sensitivities and specificities for the parameters. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 20% |
Argentina | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Portugal | 1 | <1% |
Canada | 1 | <1% |
Austria | 1 | <1% |
Unknown | 150 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 16% |
Student > Bachelor | 18 | 12% |
Student > Postgraduate | 14 | 9% |
Researcher | 14 | 9% |
Student > Ph. D. Student | 14 | 9% |
Other | 25 | 16% |
Unknown | 44 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 38% |
Agricultural and Biological Sciences | 13 | 8% |
Biochemistry, Genetics and Molecular Biology | 12 | 8% |
Nursing and Health Professions | 6 | 4% |
Immunology and Microbiology | 6 | 4% |
Other | 11 | 7% |
Unknown | 47 | 31% |