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The CaMKII/NMDAR complex as a molecular memory

Overview of attention for article published in Molecular Brain, February 2013
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1 Facebook page


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The CaMKII/NMDAR complex as a molecular memory
Published in
Molecular Brain, February 2013
DOI 10.1186/1756-6606-6-10
Pubmed ID

CaMKII is a major synaptic protein that is activated during the induction of long-term potentiation (LTP) by the Ca2+ influx through NMDARs. This activation is required for LTP induction, but the role of the kinase in the maintenance of LTP is less clear. Elucidating the mechanisms of maintenance may provide insights into the molecular processes that underlie the stability of stored memories. In this brief review, we will outline the criteria for evaluating an LTP maintenance mechanism. The specific hypothesis evaluated is that LTP is maintained by the complex of activated CaMKII with the NMDAR. The evidence in support of this hypothesis is substantial, but further experiments are required, notably to determine the time course and persistence of complex after LTP induction. Additional work is also required to elucidate how the CaMKII/NMDAR complex produces the structural growth of the synapse that underlies late LTP. It has been proposed by Frey and Morris that late LTP involves the setting of a molecular tag during LTP induction, which subsequently allows the activated synapse to capture the proteins responsible for late LTP. However, the molecular processes by which this leads to the structural growth that underlies late LTP are completely unclear. Based on known binding reactions, we suggest the first molecularly specific version of tag/capture hypothesis: that the CaMKII/NMDAR complex, once formed, serves as a tag, which then leads to a binding cascade involving densin, delta-catenin, and N-cadherin (some of which are newly synthesized). Delta-catenin binds AMPA-binding protein (ABP), leading to the LTP-induced increase in AMPA channel content. The addition of postsynaptic N-cadherin, and the complementary increase on the presynaptic side, leads to a trans-synaptically coordinated increase in synapse size (and more release sites). It is suggested that synaptic strength is stored stably through the combined actions of the CaMKII/NMDAR complex and N-cadherin dimers. These N-cadherin pairs have redundant storage that could provide informational stability in a manner analogous to the base-pairing in DNA.

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Mendeley readers

The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 3 1%
United States 3 1%
United Kingdom 2 <1%
Canada 2 <1%
Portugal 1 <1%
Hungary 1 <1%
Spain 1 <1%
Russia 1 <1%
Unknown 247 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 28%
Student > Master 45 17%
Student > Bachelor 32 12%
Researcher 31 12%
Professor 19 7%
Other 35 13%
Unknown 27 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 115 44%
Neuroscience 54 21%
Biochemistry, Genetics and Molecular Biology 23 9%
Medicine and Dentistry 15 6%
Psychology 6 2%
Other 15 6%
Unknown 33 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2013.
All research outputs
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Outputs from Molecular Brain
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Outputs of similar age
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Outputs of similar age from Molecular Brain
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Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.