@mitchellblee33 @AdamsBioAging @Blagosklonny Indeed, and chronic mTOR activation in brain seems to cause an amyloid-independent dementia through Tau https://t.co/UO9a5X7RCt https://t.co/tRC5ERqDd1 All things being equal, I'd take Abeta without dementia
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22,968 followers
They report microglial hyperactivation of mTOR by knockout of Tsc1 reduces amyloid beta in the 5xFAD mouse model of AD. That makes sense. Others have reported that tuberous sclerosis complex, caused by Tsc1/Tsc2 mutations, is a non-amyloid tauopathy: https
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RT @SHJerryWang2: Excited to share our new paper showing TSC is an amyloid-independent mixed 3R/4R tauopathy. @JayBLusk @DukePathDept @Duke…
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RT @DukeBrain: Tuberous sclerosis is a rare genetic disease that spurs benign tumors in the brain + body. It can also spark psychiatric pro…