Title |
Salvage surgery for local failures after stereotactic ablative radiotherapy for early stage non-small cell lung cancer
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Published in |
Radiation Oncology, October 2016
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DOI | 10.1186/s13014-016-0706-7 |
Pubmed ID | |
Authors |
Naomi E. Verstegen, Alexander P. W. M. Maat, Frank J. Lagerwaard, Marinus A. Paul, Michel I Versteegh, Joris J. Joosten, Willem Lastdrager, Egbert F. Smit, Ben J. Slotman, Joost J. M. E. Nuyttens, Suresh Senan |
Abstract |
The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases. Complications were scored using the Dindo-Clavien-classification. Nine patients who underwent surgery for a local recurrence were identified. Median time to local recurrence was 22 months. Recurrences were diagnosed with CT- and/or 18FDG-PET-imaging, with four patients also having a pre-surgical pathological diagnosis. Extensive adhesions were observed during two resections, requiring conversion from a thoracoscopic procedure to thoracotomy during one of these procedures. Three patients experienced complications post-surgery; grade 2 (N = 2) and grade 3a (N = 1), respectively. All resection specimens showed viable tumor cells. Median length of hospital stay was 8 days (range 5-15 days) and 30-day mortality was 0 %. Lymph node dissection revealed mediastinal metastases in 3 patients, all of whom received adjuvant therapy. Our experience with nine surgical procedures for local recurrences post-SABR revealed two grade IIIa complications, and a 30-day mortality of 0 %, suggesting that salvage surgery can be safely performed after SABR. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 20% |
Spain | 1 | 20% |
United States | 1 | 20% |
Cyprus | 1 | 20% |
United Kingdom | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 12% |
Other | 4 | 12% |
Professor | 3 | 9% |
Student > Master | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 7 | 21% |
Unknown | 10 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 39% |
Psychology | 2 | 6% |
Linguistics | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 15 | 45% |