Title |
Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease
|
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Published in |
Respiratory Research, October 2016
|
DOI | 10.1186/s12931-016-0442-4 |
Pubmed ID | |
Authors |
Adelaida Lamas, Jamie Marshburn, Vandy P. Stober, Scott H. Donaldson, Stavros Garantziotis |
Abstract |
Cystic fibrosis (CF) is a chronic inflammatory disease that is affecting thousands of patients worldwide. Adjuvant anti-inflammatory treatment is an important component of cystic fibrosis treatment, and has shown promise in preserving lung function and prolonging life expectancy. Inhaled high molecular weight hyaluronan (HMW-HA) is reported to improve tolerability of hypertonic saline and thus increase compliance, and has been approved in some European countries for use as an adjunct to hypertonic saline treatment in cystic fibrosis. However, there are theoretical concerns that HMW-HA breakdown products may be pro-inflammatory. In this clinical pilot study we show that sputum cytokines in CF patients receiving HMW-HA are not increased, and therefore HMW-HA does not appear to adversely affect inflammatory status in CF airways. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 18% |
Researcher | 4 | 12% |
Student > Master | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 7 | 21% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Nursing and Health Professions | 2 | 6% |
Chemistry | 2 | 6% |
Other | 5 | 15% |
Unknown | 7 | 21% |