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Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles

Overview of attention for article published in BMC Biology, February 2013
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Title
Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles
Published in
BMC Biology, February 2013
DOI 10.1186/1741-7007-11-13
Pubmed ID
Authors

Jingxia Xu, Thomas Gridley

Abstract

In the mouse ovary, oocytes initially develop in clusters termed germ-cell nests. Shortly after birth, these germ-cell nests break apart, and the oocytes individually become surrounded by somatic granulosa cells to form primordial follicles. Notch signaling plays essential roles during oogenesis in Drosophila, and recent studies have suggested that Notch signaling also plays an essential role during oogenesis and ovary development in mammals. However, no in vivo loss-of-function studies have been performed to establish whether Notch family receptors have an essential physiological role during normal ovarian development in mutant mice.

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Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Portugal 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 28%
Student > Bachelor 7 14%
Student > Master 7 14%
Professor > Associate Professor 5 10%
Student > Doctoral Student 4 8%
Other 4 8%
Unknown 9 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 36%
Biochemistry, Genetics and Molecular Biology 15 30%
Medicine and Dentistry 4 8%
Veterinary Science and Veterinary Medicine 1 2%
Engineering 1 2%
Other 0 0%
Unknown 11 22%