Title |
Reduced viral burden in paralytic compared to furious canine rabies is associated with prominent inflammation at the brainstem level
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Published in |
BMC Veterinary Research, February 2013
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DOI | 10.1186/1746-6148-9-31 |
Pubmed ID | |
Authors |
Shanop Shuangshoti, Nischol Thepa, Pornchai Phukpattaranont, Akanitt Jittmittraphap, Nirun Intarut, Veera Tepsumethanon, Supaporn Wacharapluesadee, Paul Scott Thorner, Thiravat Hemachudha |
Abstract |
The mechanisms that differentiate rabies infections into furious and paralytic forms remain undetermined. There are no neuropathological features in human brains that distinguish furious and paralytic rabies. This could be due to methodology and/or examination of specimens late in the disease course.In this study, postmortem examination of brain (5 furious and 5 paralytic) and spinal cord (3 furious and 3 paralytic) specimens was performed in 10 rabies-infected dogs, sacrificed shortly after developing the illness. Rabies virus (RABV) antigen (percentage of positive neurons, average antigen area in positive neurons and average antigen area per neuron) and RNA were quantified at 15 different central nervous system (CNS) regions. The distribution and degree of inflammation were also studied. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
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South Africa | 2 | 3% |
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Researcher | 11 | 15% |
Student > Master | 11 | 15% |
Student > Bachelor | 10 | 14% |
Student > Ph. D. Student | 6 | 8% |
Other | 4 | 5% |
Other | 11 | 15% |
Unknown | 20 | 27% |
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Other | 7 | 10% |
Unknown | 19 | 26% |