@Eric_Fauman There is an association with the ratio between two neighboring NMR peaks .. https://t.co/zLBmkPNDXj We argued that this could be a ratio with background noise, but it may also be a substrate-product pair, in which case identification of this r
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@BiswapriyaMisra @ETH_en Correct - but I like to turn the argument on the head: if there is a significant p-gain, it means that there must be a relation - hence testing all-against-all. Check out Fig 4 of https://t.co/zLBmkPNDXj : SNP rs4488133 associat
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@Angrist_Fusion @Metabolon @NgaleHealth ... Fig 5 in https://t.co/zLBmkPNDXj gives an example of the same loci seen by @Biocrates_ , @Metabolon and @NumaresA https://t.co/Vq8g2UE6aT
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@Angrist_Fusion @Metabolon @NgaleHealth mQTLs can serve as benchmark for specific metabolites, since SNPs are always causal and effect sizes fixed - strength of assoc. then only depends on exp. variance of the measurement https://t.co/zLBmkPNDXj