Title |
Analyzing miRNA co-expression networks to explore TF-miRNA regulation
|
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Published in |
BMC Bioinformatics, May 2009
|
DOI | 10.1186/1471-2105-10-163 |
Pubmed ID | |
Authors |
Sanghamitra Bandyopadhyay, Malay Bhattacharyya |
Abstract |
Current microRNA (miRNA) research in progress has engendered rapid accumulation of expression data evolving from microarray experiments. Such experiments are generally performed over different tissues belonging to a specific species of metazoan. For disease diagnosis, microarray probes are also prepared with tissues taken from similar organs of different candidates of an organism. Expression data of miRNAs are frequently mapped to co-expression networks to study the functions of miRNAs, their regulation on genes and to explore the complex regulatory network that might exist between Transcription Factors (TFs), genes and miRNAs. These directions of research relating miRNAs are still not fully explored, and therefore, construction of reliable and compatible methods for mining miRNA co-expression networks has become an emerging area. This paper introduces a novel method for mining the miRNA co-expression networks in order to obtain co-expressed miRNAs under the hypothesis that these might be regulated by common TFs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 2% |
Brazil | 2 | 2% |
Germany | 1 | <1% |
Australia | 1 | <1% |
Sweden | 1 | <1% |
Norway | 1 | <1% |
Mexico | 1 | <1% |
India | 1 | <1% |
Russia | 1 | <1% |
Other | 1 | <1% |
Unknown | 110 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 39 | 32% |
Student > Ph. D. Student | 25 | 20% |
Professor > Associate Professor | 13 | 11% |
Professor | 10 | 8% |
Student > Master | 8 | 7% |
Other | 22 | 18% |
Unknown | 6 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 71 | 58% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Medicine and Dentistry | 11 | 9% |
Computer Science | 10 | 8% |
Engineering | 3 | 2% |
Other | 8 | 7% |
Unknown | 7 | 6% |