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Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs

Overview of attention for article published in BMC Veterinary Research, February 2013
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30 Mendeley
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Title
Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs
Published in
BMC Veterinary Research, February 2013
DOI 10.1186/1746-6148-9-27
Pubmed ID
Authors

Gonzalo Suárez, Luis Alvarez, Daniel Castells, Oscar Correa, Pietro Fagiolino, Carlos Lanusse

Abstract

Several oral ivermectin (IVM) formulations for use in sheep are available in the pharmaceutical veterinary market in different countries. All of them are indicated at the same dose rate to treat the gastrointestinal nematodes. However, there is a lack of information on the relative systemic exposure (plasma bioavailability) and clinical efficacy among oral formulations routinely used in sheep. The main goal of the work reported here was to perform a pharmaco-parasitological assessment of three different IVM oral formulations in lambs infected with multiple resistant gastrointestinal nematodes. The comparative drug systemic exposure (IVM plasma concentrations) and nematodicidal efficacies (clinical efficacy) in lambs were determined for a reference (RF) and two different test (T1, T2) IVM oral formulations. One hundred and fifty six (n= 156) healthy Corriedale lambs, naturally infected with multiple resistant gastrointestinal nematodes were allocated into four experimental groups (n=39). Animals in each group received treatment (200 μg/kg) with either the RF, one of the test IVM formulations or were kept as untreated control. Blood samples were collected over 15 days post-treatment (n=8). The IVM plasma concentrations were measured by high performance liquid chromatography with fluorescence detection. The faecal nematode egg count reduction test (FECRT) (n=39) and evaluation of the clinical efficacy were performed at day 14 post-treatment (n=6), where a predominance of IVM highly resistant nematodes was observed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Uruguay 2 7%
United States 1 3%
Romania 1 3%
Australia 1 3%
Unknown 25 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Student > Master 5 17%
Student > Ph. D. Student 4 13%
Student > Bachelor 2 7%
Professor 2 7%
Other 8 27%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 37%
Veterinary Science and Veterinary Medicine 5 17%
Medicine and Dentistry 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Environmental Science 1 3%
Other 4 13%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2013.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from BMC Veterinary Research
#1,630
of 2,630 outputs
Outputs of similar age
#120,423
of 163,112 outputs
Outputs of similar age from BMC Veterinary Research
#9
of 18 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,630 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,112 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.