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Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice

Overview of attention for article published in BMC Genomics, February 2013
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Title
Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice
Published in
BMC Genomics, February 2013
DOI 10.1186/1471-2164-14-113
Pubmed ID
Authors

Ferhat Ozturk, You Li, Xiujuan Zhu, Chittibabu Guda, Ali Nawshad

Abstract

In humans, cleft palate (CP) accounts for one of the largest number of birth defects with a complex genetic and environmental etiology. TGFβ3 has been established as an important regulator of palatal fusion in mice and it has been shown that TGFβ3-null mice exhibit CP without any other major deformities. However, the genes that regulate cellular decisions and molecular mechanisms maintained by the TGFβ3 pathway throughout palatogenesis are predominantly unexplored. Our objective in this study was to analyze global transcriptome changes within the palate during different gestational ages within TGFβ3 knockout mice to identify TGFβ3-associated genes previously unknown to be associated with the development of cleft palate. We used deep sequencing technology, RNA-Seq, to analyze the transcriptome of TGFβ3 knockout mice at crucial stages of palatogenesis, including palatal growth (E14.5), adhesion (E15.5), and fusion (E16.5).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Korea, Republic of 1 2%
Australia 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 27%
Researcher 7 13%
Student > Bachelor 5 9%
Student > Postgraduate 5 9%
Student > Master 4 7%
Other 9 16%
Unknown 10 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 29%
Biochemistry, Genetics and Molecular Biology 12 22%
Medicine and Dentistry 12 22%
Engineering 2 4%
Computer Science 2 4%
Other 2 4%
Unknown 9 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2013.
All research outputs
#20,182,546
of 22,696,971 outputs
Outputs from BMC Genomics
#9,247
of 10,616 outputs
Outputs of similar age
#169,698
of 192,959 outputs
Outputs of similar age from BMC Genomics
#104
of 122 outputs
Altmetric has tracked 22,696,971 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,616 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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