Title |
Genotypic but not phenotypic historical contingency revealed by viral experimental evolution
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Published in |
BMC Ecology and Evolution, February 2013
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DOI | 10.1186/1471-2148-13-46 |
Pubmed ID | |
Authors |
Stéphanie Bedhomme, Guillaume Lafforgue, Santiago F Elena |
Abstract |
The importance of historical contingency in determining the potential of viral populations to evolve has been largely unappreciated. Identifying the constraints imposed by past adaptations is, however, of importance for understanding many questions in evolutionary biology, such as the evolution of host usage dynamics by multi-host viruses or the emergence of escape mutants that persist in the absence of antiviral treatments. To address this issue, we undertook an experimental approach in which sixty lineages of Tobacco etch potyvirus that differ in their past evolutionary history and degree of adaptation to Nicotiana tabacum were allowed to adapt to this host for 15 rounds of within host multiplication and transfer. We thereafter evaluated the degree of adaptation to the new host as well as to the original ones and characterized the consensus sequence of each lineage. |
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