Title |
Prognostic significance of miR-194 in endometrial cancer
|
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Published in |
Biomarker Research, February 2013
|
DOI | 10.1186/2050-7771-1-12 |
Pubmed ID | |
Authors |
Haiyan Zhai, Mihriban Karaayvaz, Peixin Dong, Noriaki Sakuragi, Jingfang Ju |
Abstract |
Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 33% |
Professor > Associate Professor | 2 | 13% |
Student > Master | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 3 | 20% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 33% |
Medicine and Dentistry | 5 | 33% |
Agricultural and Biological Sciences | 2 | 13% |
Arts and Humanities | 1 | 7% |
Unknown | 2 | 13% |