Title |
In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy
|
---|---|
Published in |
Critical Reviews in Diagnostic Imaging, February 2013
|
DOI | 10.1186/1532-429x-15-19 |
Pubmed ID | |
Authors |
Michael S Dodd, Vicky Ball, Rosalind Bray, Houman Ashrafian, Hugh Watkins, Kieran Clarke, Damian J Tyler |
Abstract |
Alterations in cardiac metabolism accompany many diseases of the heart. The advent of cardiac hyperpolarized magnetic resonance spectroscopy (MRS), via dynamic nuclear polarization (DNP), has enabled a greater understanding of the in vivo metabolic changes that occur as a consequence of myocardial infarction, hypertrophy and diabetes. However, all cardiac studies performed to date have focused on rats and larger animals, whereas more information could be gained through the study of transgenic mouse models of heart disease. Translation from the rat to the mouse is challenging, due in part to the reduced heart size (1/10(th)) and the increased heart rate (50%) in the mouse compared to the rat. |
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