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Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study

Overview of attention for article published in Lipids in Health and Disease, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog

Readers on

mendeley
45 Mendeley
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Title
Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
Published in
Lipids in Health and Disease, October 2016
DOI 10.1186/s12944-016-0344-y
Pubmed ID
Authors

Quanri Liu, Yu An, Huanling Yu, Yanhui Lu, Lingli Feng, Chao Wang, Rong Xiao

Abstract

To investigate the relationship between oxysterols and mild cognitive impairment (MCI) in a matched case-control study. The plasma levels of four oxysterols, 27-hydroxycholesterol (27-OHC), 24S-hydroxycholesterol (24S-OHC), 7α-hydroxycholesterol (7α-OHC) and 7β-hydroxycholesterol (7β-OHC), were analyzed by High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) and compared between 70 MCI patients and 140 matched controls with normal cognition. The odds ratio (OR) was calculated using logistic analyses to assess the association between oxysterols and MCI. Compared with controls with normal cognition, plasma level of 27-OHC was significantly higher in MCI patients. Logistic analyses suggested high plasma level of 27-OHC was significantly associated with MCI even after multivariate adjustment (OR = 2.86, 95 % CI: 1.52 ~ 5.37). Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 11%
Researcher 5 11%
Student > Master 5 11%
Student > Bachelor 4 9%
Student > Doctoral Student 3 7%
Other 7 16%
Unknown 16 36%
Readers by discipline Count As %
Neuroscience 5 11%
Medicine and Dentistry 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Biochemistry, Genetics and Molecular Biology 3 7%
Psychology 2 4%
Other 6 13%
Unknown 22 49%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#2,459,869
of 22,893,031 outputs
Outputs from Lipids in Health and Disease
#170
of 1,450 outputs
Outputs of similar age
#44,794
of 320,105 outputs
Outputs of similar age from Lipids in Health and Disease
#6
of 38 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,450 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,105 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.