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Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine

Overview of attention for article published in BMC Emergency Medicine, April 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)

Mentioned by

blogs
1 blog

Citations

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61 Dimensions

Readers on

mendeley
59 Mendeley
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Title
Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine
Published in
BMC Emergency Medicine, April 2009
DOI 10.1186/1471-227x-9-5
Pubmed ID
Authors

Matthew D Krasowski, Anthony F Pizon, Mohamed G Siam, Spiros Giannoutsos, Manisha Iyer, Sean Ekins

Abstract

Laboratory tests for routine drug of abuse and toxicology (DOA/Tox) screening, often used in emergency medicine, generally utilize antibody-based tests (immunoassays) to detect classes of drugs such as amphetamines, barbiturates, benzodiazepines, opiates, and tricyclic antidepressants, or individual drugs such as cocaine, methadone, and phencyclidine. A key factor in assay sensitivity and specificity is the drugs or drug metabolites that were used as antigenic targets to generate the assay antibodies. All DOA/Tox screening immunoassays can be limited by false positives caused by cross-reactivity from structurally related compounds. For immunoassays targeted at a particular class of drugs, there can also be false negatives if there is failure to detect some drugs or their metabolites within that class.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Cyprus 1 2%
Switzerland 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Other 11 19%
Student > Ph. D. Student 11 19%
Researcher 6 10%
Student > Master 5 8%
Student > Doctoral Student 3 5%
Other 14 24%
Unknown 9 15%
Readers by discipline Count As %
Medicine and Dentistry 19 32%
Chemistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Social Sciences 3 5%
Psychology 3 5%
Other 14 24%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2013.
All research outputs
#5,622,290
of 22,699,621 outputs
Outputs from BMC Emergency Medicine
#230
of 746 outputs
Outputs of similar age
#25,967
of 92,775 outputs
Outputs of similar age from BMC Emergency Medicine
#2
of 4 outputs
Altmetric has tracked 22,699,621 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 746 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,775 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.