Title |
Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine
|
---|---|
Published in |
BMC Emergency Medicine, April 2009
|
DOI | 10.1186/1471-227x-9-5 |
Pubmed ID | |
Authors |
Matthew D Krasowski, Anthony F Pizon, Mohamed G Siam, Spiros Giannoutsos, Manisha Iyer, Sean Ekins |
Abstract |
Laboratory tests for routine drug of abuse and toxicology (DOA/Tox) screening, often used in emergency medicine, generally utilize antibody-based tests (immunoassays) to detect classes of drugs such as amphetamines, barbiturates, benzodiazepines, opiates, and tricyclic antidepressants, or individual drugs such as cocaine, methadone, and phencyclidine. A key factor in assay sensitivity and specificity is the drugs or drug metabolites that were used as antigenic targets to generate the assay antibodies. All DOA/Tox screening immunoassays can be limited by false positives caused by cross-reactivity from structurally related compounds. For immunoassays targeted at a particular class of drugs, there can also be false negatives if there is failure to detect some drugs or their metabolites within that class. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Cyprus | 1 | 2% |
Switzerland | 1 | 2% |
Unknown | 55 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 11 | 19% |
Student > Ph. D. Student | 11 | 19% |
Researcher | 6 | 10% |
Student > Master | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 14 | 24% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 32% |
Chemistry | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Social Sciences | 3 | 5% |
Psychology | 3 | 5% |
Other | 14 | 24% |
Unknown | 10 | 17% |