Title |
Rationale and design of a randomized controlled trial of the effect of retinol and vitamin D supplementation on treatment in active pulmonary tuberculosis patients with diabetes
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Published in |
BMC Infectious Diseases, February 2013
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DOI | 10.1186/1471-2334-13-104 |
Pubmed ID | |
Authors |
Qiuzhen Wang, Aiguo Ma, Ib Christian Bygbjerg, Xiuxia Han, Yufeng Liu, Shanliang Zhao, Jing Cai |
Abstract |
The association between pulmonary tuberculosis (PTB) and diabetes mellitus (DM) has been previously attracted much attention. Diabetes alters immunity to tuberculosis, leading to more frequent treatment failure in TB patients with DM. Moreover, TB and DM often coincide with micronutrients deficiencies, such as retinol and vitamin D, which are especially important to immunity of the body and may influence pancreas β-cell function. However, the effects of retinol and vitamin D supplementation in active TB patients with diabetes on treatment outcomes, immune and nutrition state are still uncertain. We are conducting a randomized controlled trial of vitamin A and/or D in active PTB patients with DM in a network of 4 TB treatment clinics to determine whether the supplementation could improve the outcome in the patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | <1% |
Germany | 1 | <1% |
South Africa | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
New Zealand | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 167 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 36 | 21% |
Student > Bachelor | 22 | 13% |
Researcher | 14 | 8% |
Lecturer | 12 | 7% |
Student > Postgraduate | 10 | 6% |
Other | 36 | 21% |
Unknown | 44 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 64 | 37% |
Nursing and Health Professions | 16 | 9% |
Agricultural and Biological Sciences | 10 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Other | 23 | 13% |
Unknown | 50 | 29% |