Title |
CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
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Published in |
Retrovirology, February 2013
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DOI | 10.1186/1742-4690-10-24 |
Pubmed ID | |
Authors |
Kieran Cashin, Lachlan R Gray, Martin R Jakobsen, Jasminka Sterjovski, Melissa J Churchill, Paul R Gorry |
Abstract |
The majority of HIV-1 subjects worldwide are infected with HIV-1 subtype C (C-HIV). Although C-HIV predominates in developing regions of the world such as Southern Africa and Central Asia, C-HIV is also spreading rapidly in countries with more developed economies and health care systems, whose populations are more likely to have access to wider treatment options, including the CCR5 antagonist maraviroc (MVC). The ability to reliably determine C-HIV coreceptor usage is therefore becoming increasingly more important. In silico V3 sequence based coreceptor usage prediction algorithms are a relatively rapid and cost effective method for determining HIV-1 coreceptor specificity. In this study, we elucidated the V3 sequence determinants of C-HIV coreceptor usage, and used this knowledge to develop and validate a novel, user friendly, and highly sensitive C-HIV specific coreceptor usage prediction algorithm. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 3% |
Unknown | 30 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 26% |
Researcher | 5 | 16% |
Student > Master | 4 | 13% |
Professor | 3 | 10% |
Other | 2 | 6% |
Other | 4 | 13% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 26% |
Agricultural and Biological Sciences | 6 | 19% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Immunology and Microbiology | 2 | 6% |
Computer Science | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |