Title |
Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
|
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Published in |
BMC Psychiatry, February 2013
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DOI | 10.1186/1471-244x-13-71 |
Pubmed ID | |
Authors |
Michael Kluge, Ulrich Hegerl, Christian Sander, Jens Dietzel, Roland Mergl, Istvan Bitter, Koen Demyttenaere, Ricardo Gusmão, Ana Gonzalez-Pinto, Victor Perez-Sola, Eduard Vieta, Georg Juckel, Ulrich S Zimmermann, Michael Bauer, Pascal Sienaert, Sónia Quintão, Marc-Andreas Edel, Csilla Bolyos, Jose Luis Ayuso-Mateos, Pilar López-García |
Abstract |
Treatment of patients with acute mania remains a considerable medical challenge since onset of action of antimanic medication is delayed for several days. Psychostimulants could have an earlier onset of action. This assumption is based on the 'vigilance regulation model of mania' which postulates that vigilance is unstable in manic patients. Accordingly, vigilance-stabilising psychostimulants could be more useful than conventional treatment in acute mania. We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania. |
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Japan | 2 | 17% |
Spain | 1 | 8% |
United Kingdom | 1 | 8% |
Egypt | 1 | 8% |
Unknown | 7 | 58% |
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Members of the public | 11 | 92% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
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Portugal | 1 | <1% |
Australia | 1 | <1% |
Unknown | 100 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 20 | 20% |
Researcher | 13 | 13% |
Student > Bachelor | 10 | 10% |
Other | 9 | 9% |
Student > Ph. D. Student | 9 | 9% |
Other | 24 | 24% |
Unknown | 17 | 17% |
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Psychology | 18 | 18% |
Nursing and Health Professions | 7 | 7% |
Neuroscience | 7 | 7% |
Business, Management and Accounting | 2 | 2% |
Other | 13 | 13% |
Unknown | 25 | 25% |