Title |
MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells
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Published in |
BMC Genomics, February 2013
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DOI | 10.1186/1471-2164-14-139 |
Pubmed ID | |
Authors |
Maria Ouzounova, Tri Vuong, Pierre-Benoit Ancey, Mylène Ferrand, Geoffroy Durand, Florence Le-Calvez Kelm, Carlo Croce, Chantal Matar, Zdenko Herceg, Hector Hernandez-Vargas |
Abstract |
A subset of breast cancer cells displays increased ability to self-renew and reproduce breast cancer heterogeneity. The characterization of these so-called putative breast tumor-initiating cells (BT-ICs) may open the road for novel therapeutic strategies. As microRNAs (miRNAs) control developmental programs in stem cells, BT-ICs may also rely on specific miRNA profiles for their sustained activity. To explore the notion that miRNAs may have a role in sustaining BT-ICs, we performed a comprehensive profiling of miRNA expression in a model of putative BT-ICs enriched by non-attachment growth conditions. |
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Mendeley readers
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Computer Science | 2 | 3% |
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