Title |
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
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Published in |
Molecular Brain, November 2009
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DOI | 10.1186/1756-6606-2-35 |
Pubmed ID | |
Authors |
Oksana Kaidanovich-Beilin, Tatiana V Lipina, Keizo Takao, Matthijs van Eede, Satoko Hattori, Christine Laliberté, Mustafa Khan, Kenichi Okamoto, John W Chambers, Paul J Fletcher, Katrina MacAulay, Bradley W Doble, Mark Henkelman, Tsuyoshi Miyakawa, John Roder, James R Woodgett |
Abstract |
Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate two related proteins: GSK-3alpha and GSK-3beta. Mice lacking a functional GSK-3alpha gene were engineered in our laboratory; they are viable and display insulin sensitivity. In this study, we have characterized brain functions of GSK-3alpha KO mice by using a well-established battery of behavioral tests together with neurochemical and neuroanatomical analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
France | 1 | <1% |
India | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
Unknown | 109 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 18% |
Student > Ph. D. Student | 20 | 17% |
Student > Bachelor | 18 | 16% |
Student > Master | 12 | 10% |
Professor | 8 | 7% |
Other | 19 | 17% |
Unknown | 17 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 26 | 23% |
Neuroscience | 19 | 17% |
Biochemistry, Genetics and Molecular Biology | 17 | 15% |
Psychology | 9 | 8% |
Medicine and Dentistry | 7 | 6% |
Other | 17 | 15% |
Unknown | 20 | 17% |