Title |
Complete genome sequence of Treponema pallidum strain DAL-1
|
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Published in |
Environmental Microbiome, October 2012
|
DOI | 10.4056/sigs.2615838 |
Pubmed ID | |
Authors |
Marie Zobaníková, Pavol Mikolka, Darina Čejková, Petra Pospíšilová, Lei Chen, Michal Strouhal, Xiang Qin, George M. Weinstock, David Šmajs |
Abstract |
Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain. |
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