Title |
Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for Chronic Daily Headache: Protocol for a randomized clinical trial
|
---|---|
Published in |
Trials, April 2011
|
DOI | 10.1186/1745-6215-12-97 |
Pubmed ID | |
Authors |
Christopher E Ramsden, J Douglas Mann, Keturah R Faurot, Chanee Lynch, Syed Taha Imam, Beth A MacIntosh, Joseph R Hibbeln, James Loewke, Sunyata Smith, Rebecca Coble, Chirayath Suchindran, Susan A Gaylord |
Abstract |
Targeted analgesic dietary interventions are a promising strategy for alleviating pain and improving quality of life in patients with persistent pain syndromes, such as chronic daily headache (CDH). High intakes of the omega-6 (n-6) polyunsaturated fatty acids (PUFAs), linoleic acid (LA) and arachidonic acid (AA) may promote physical pain by increasing the abundance, and subsequent metabolism, of LA and AA in immune and nervous system tissues. Here we describe methodology for an ongoing randomized clinical trial comparing the metabolic and clinical effects of a low n-6, average n-3 PUFA diet, to the effects of a low n-6 plus high n-3 PUFA diet, in patients with CDH. Our primary aim is to determine if: A) both diets reduce n-6 PUFAs in plasma and erythrocyte lipid pools, compared to baseline; and B) the low n-6 plus high n-3 diet produces a greater decline in n-6 PUFAs, compared to the low n-6 diet alone. Secondary clinical outcomes include headache-specific quality-of-life, and headache frequency and intensity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 95 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 20% |
Student > Ph. D. Student | 10 | 10% |
Researcher | 10 | 10% |
Student > Master | 10 | 10% |
Other | 9 | 9% |
Other | 17 | 17% |
Unknown | 23 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 37% |
Agricultural and Biological Sciences | 8 | 8% |
Nursing and Health Professions | 7 | 7% |
Psychology | 5 | 5% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Other | 11 | 11% |
Unknown | 27 | 27% |