The shortlisted Bayesian adaptive designs improved power or lowered the average sample size substantially. https://t.co/VZEp0EQCd2
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“The advantages of Bayesian adaptive designs are particularly desirable in oncology, where clinical trial failure rates are the highest among all medical specialties” https://t.co/VZEp0EQCd2
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Reminds me of this “re-execution” of a chemo RCT substituting Bayesian adaptive in place of Frequentist Bayesian adaptive reduced the average sample size by up to 37% when there was no clinical effect and by up to 17% at the target clinical effect https
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Great educational thread, thankyou- benefits of lower sample size requirements with Bayesian designs of growing relevance in cancer trials - example by @DrWeiHong and colleagues https://t.co/7BojvtRiRA