Title |
Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma
|
---|---|
Published in |
Respiratory Research, March 2013
|
DOI | 10.1186/1465-9921-14-28 |
Pubmed ID | |
Authors |
Keiko Kan-o, Yuko Matsunaga, Satoru Fukuyama, Atsushi Moriwaki, Hiroko Hirai-Kitajima, Takehiko Yokomizo, Kosuke Aritake, Yoshihiro Urade, Yoichi Nakanishi, Hiromasa Inoue, Koichiro Matsumoto |
Abstract |
Clinical studies showed the contribution of viral infection to the development of asthma. Although mast cells have multiple roles in the pathogenesis of allergic asthma, their role of in the virus-associated pathogenesis of asthma remains unknown. Most respiratory viruses generate double-stranded (ds) RNA during their replication. dsRNA provokes innate immune responses. We recently showed that an administration of polyinocinic polycytidilic acid (poly IC), a mimetic of viral dsRNA, during allergen sensitization augments airway eosinophilia and hyperresponsiveness in mice via enhanced production of IL-13. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 33% |
Canada | 1 | 33% |
France | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 27% |
Student > Ph. D. Student | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Student > Master | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 47% |
Agricultural and Biological Sciences | 3 | 20% |
Immunology and Microbiology | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 0 | 0% |
Unknown | 1 | 7% |