Title |
Comparative analysis of circulating dendritic cell subsets in patients with atopic diseases and sarcoidosis
|
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Published in |
Respiratory Research, March 2013
|
DOI | 10.1186/1465-9921-14-29 |
Pubmed ID | |
Authors |
Yumeko Hayashi, Yoshiki Ishii, Mitsumi Hata-Suzuki, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Takeshi Fukuda |
Abstract |
Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the initiation and modulation of immune responses. Human circulating blood DCs are divided into two major subsets: myeloid DCs (mDCs); and plasmacytoid DCs (pDCs). Furthermore, mDCs are subdivided into two subsets: Th1-promoting mDCs (mDC1s); and Th2-promoting mDCs (mDC2s). Although CD1a, CD1c, and CD141 are generally used for classifying mDC subsets, their adequacy as a specific marker remains unclear. We performed this study to compare circulating mDC, pDC, mDC1, and mDC2 subsets between Th1- and Th2-mediated diseases using CD1a and CD141, and to analyze the adequacy of CD1a and CD141 as a marker for mDC1s and mDC2s, respectively. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
United States | 1 | 2% |
Unknown | 51 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 28% |
Student > Ph. D. Student | 9 | 17% |
Student > Master | 9 | 17% |
Professor > Associate Professor | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 5 | 9% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 30% |
Agricultural and Biological Sciences | 10 | 19% |
Immunology and Microbiology | 9 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Chemistry | 2 | 4% |
Other | 3 | 6% |
Unknown | 10 | 19% |