Title |
Endotoxaemia is common in children with Plasmodium falciparummalaria
|
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Published in |
BMC Infectious Diseases, March 2013
|
DOI | 10.1186/1471-2334-13-117 |
Pubmed ID | |
Authors |
Peter Olupot-Olupot, Britta C Urban, Julie Jemutai, Julius Nteziyaremye, Harry M Fanjo, Henry Karanja, Japhet Karisa, Paul Ongodia, Patrick Bwonyo, Evelyn N Gitau, Alison Talbert, Samuel Akech, Kathryn Maitland |
Abstract |
Children presenting to hospital with recent or current Plasmodium falciparum malaria are at increased the risk of invasive bacterial disease, largely enteric gram-negative organisms (ENGO), which is associated with increased mortality and recurrent morbidity. Although incompletely understood, the most likely source of EGNO is the bowel. We hypothesised that as a result of impaired gut-barrier function endotoxin (lipopolysaccharide), present in the cell-wall of EGNO and in substantial quantities in the gut, is translocated into the bloodstream, and contributes to the pathophysiology of children with severe malaria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Kenya | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 19% |
Researcher | 8 | 11% |
Student > Ph. D. Student | 7 | 9% |
Student > Bachelor | 6 | 8% |
Student > Postgraduate | 4 | 5% |
Other | 10 | 14% |
Unknown | 25 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 32% |
Agricultural and Biological Sciences | 8 | 11% |
Nursing and Health Professions | 3 | 4% |
Computer Science | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 7 | 9% |
Unknown | 26 | 35% |