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Mendeley readers
| Title |
Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65
|
|---|---|
| Published in |
Journal of Biomedical Science, February 2013
|
| DOI | 10.1186/1423-0127-20-13 |
| Pubmed ID | |
| Authors |
Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Luis F Jave-Suárez, Ruth De Célis-Carrillo, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomeli, Pablo Cesar Ortiz-Lazareno |
| Abstract |
In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and resistance to chemotherapy and this factor regulates several pathways that promote tumor survival including some antiapoptotic proteins such as Bcl-2 and Bcl-XL. In this study, we investigated, in U937 human leukemia cells, the effects of PTX and the MG132 proteasome inhibitor, drugs that can disrupt the NF-κB pathway. For this, we evaluated viability, apoptosis, cell cycle, caspases-3, -8, -9, cytochrome c release, mitochondrial membrane potential loss, p65 phosphorylation, and the modification in the expression of pro- and antiapoptotic genes, and the Bcl-2 and Bcl-XL antiapoptotic proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | 6% |
| India | 1 | 3% |
| Unknown | 30 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 33% |
| Researcher | 8 | 24% |
| Student > Master | 4 | 12% |
| Student > Doctoral Student | 1 | 3% |
| Professor | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Medicine and Dentistry | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 5 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Immunology and Microbiology | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 8 | 24% |