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Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches’ broom disease

Overview of attention for article published in BMC Chemistry, March 2013
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Title
Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches’ broom disease
Published in
BMC Chemistry, March 2013
DOI 10.1186/1752-153x-7-48
Pubmed ID
Authors

Manoelito C Santos Junior, Sandra Aparecida de Assis, Aristóteles Góes-Neto, Ângelo Amâncio Duarte, Ricardo José Alves, Moacyr Comar Junior, Alex Gutterres Taranto

Abstract

The witches' broom disease is a plague caused by Moniliophthora perniciosa in the Theobroma cacao, which has been reducing the cocoa production since 1989. This issue motivated a genome project that has showing several new molecular targets, which can be developed inhibitors in order to control the plague. Among the molecular targets obtained, the UDP-N-acetylglucosamine pyrophosphorylase (UNAcP) is a key enzyme to construct the fungal cell wall. The inhibition of this enzyme results in the fungal cell death.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 7%
Colombia 1 3%
United States 1 3%
Unknown 26 87%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 23%
Student > Ph. D. Student 4 13%
Researcher 4 13%
Professor 3 10%
Professor > Associate Professor 3 10%
Other 7 23%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 43%
Biochemistry, Genetics and Molecular Biology 4 13%
Chemistry 4 13%
Computer Science 2 7%
Engineering 2 7%
Other 3 10%
Unknown 2 7%