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The efficacy and safety of a nicotine conjugate vaccine (NicVAX®) or placebo co-administered with varenicline (Champix®) for smoking cessation: study protocol of a phase IIb, double blind, randomized…

Overview of attention for article published in BMC Public Health, December 2012
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3 X users
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1 Facebook page

Citations

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28 Dimensions

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65 Mendeley
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Title
The efficacy and safety of a nicotine conjugate vaccine (NicVAX®) or placebo co-administered with varenicline (Champix®) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial
Published in
BMC Public Health, December 2012
DOI 10.1186/1471-2458-12-1052
Pubmed ID
Authors

Philippe HJ Hoogsteder, Daniel Kotz, Paul I van Spiegel, Wolfgang Viechtbauer, Ruth Brauer, Paul D Kessler, Matthew W Kalnik, Raafat EF Fahim, Onno CP van Schayck

Abstract

A potential new treatment in smoking cessation and relapse prevention is nicotine vaccination which is based on active immunization against the nicotine molecule. This immunization will elicit the immune system to produce nicotine-specific antibodies that sequester nicotine in the blood stream, after inhaling tobacco products. The resulting antibody-antigen is too large to cross the blood-brain barrier and is therefore postulated to attenuate the rewarding effect of nicotine by preventing the latter from reaching its receptors in the brain and causing the release of dopamine. The aim of this paper is to describe the design of a phase IIb, multi-center, double blind, randomized, placebo controlled trial to assess the efficacy of the nicotine vaccine NicVAX® co-administered with varenicline (Champix®) and intensive counseling as an aid in smoking cessation and relapse prevention.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Canada 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 15%
Student > Ph. D. Student 8 12%
Other 6 9%
Student > Bachelor 6 9%
Researcher 6 9%
Other 12 18%
Unknown 17 26%
Readers by discipline Count As %
Medicine and Dentistry 21 32%
Psychology 6 9%
Agricultural and Biological Sciences 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Nursing and Health Professions 2 3%
Other 9 14%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2015.
All research outputs
#13,434,287
of 23,192,960 outputs
Outputs from BMC Public Health
#9,473
of 15,140 outputs
Outputs of similar age
#156,986
of 280,421 outputs
Outputs of similar age from BMC Public Health
#155
of 296 outputs
Altmetric has tracked 23,192,960 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 15,140 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,421 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 296 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.