Title |
Cellular phosphoinositides and the maturation of bluetongue virus, a non-enveloped capsid virus
|
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Published in |
Virology Journal, March 2013
|
DOI | 10.1186/1743-422x-10-73 |
Pubmed ID | |
Authors |
Bishnupriya Bhattacharya, Polly Roy |
Abstract |
Bluetongue virus (BTV), a member of Orbivirus genus in the Reoviridae family is a double capsid virus enclosing a genome of 10 double-stranded RNA segments. A non-structural protein of BTV, NS3, which is associated with cellular membranes and interacts with outer capsid proteins, has been shown to be involved in virus morphogenesis in infected cells. In addition, studies have also shown that during the later stages of virus infection NS3 behaves similarly to HIV protein Gag, an enveloped viral protein. Since Gag protein is known to interact with membrane lipid phosphatidylinositol (4,5) bisphosphate [PI(4,5)P2] and one of the known binding partners of NS3, cellular protein p11 also interacts with annexin a PI(4,5)P2 interacting protein, this study was designed to understand the role of this negatively charged membrane lipid in BTV assembly and maturation. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 23 | 92% |
Demographic breakdown
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Student > Bachelor | 4 | 16% |
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Professor | 2 | 8% |
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Other | 2 | 8% |
Unknown | 2 | 8% |
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Unknown | 2 | 8% |