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Mendeley readers
Attention Score in Context
| Title |
Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors Aedes aegypti and Aedes albopictus from Malaysia
|
|---|---|
| Published in |
Parasites & Vectors, March 2015
|
| DOI | 10.1186/s13071-015-0797-2 |
| Pubmed ID | |
| Authors |
Intan H Ishak, Zairi Jaal, Hilary Ranson, Charles S Wondji |
| Abstract |
Knowledge on the extent, distribution and mechanisms of insecticide resistance is essential for successful insecticide-based dengue control interventions. Here, we report an extensive resistance profiling of the dengue vectors Aedes aegypti and Aedes albopictus across Malaysia and establish the contribution of knockdown resistance mechanism revealing significant contrast between both species. Aedes mosquitoes were collected from four states in Malaysia in 2010 using ovitraps and tested against six major insecticides using WHO bioassays. Knockdown resistance (kdr) was investigated in both species. A moderate resistance to temephos was detected from samples collected in 2010 in Penang, Kuala Lumpur, Johor Bharu and Kota Bharu (1.5 < RR < 3.3). A widespread and multiple resistances was observed in Ae. aegypti particularly against pyrethroids, DDT and bendiocarb. Mosquitoes from Kuala Lumpur consistently had the highest resistance levels and was the only population showing a moderate resistance to malathion (91% mortality). The resistance profile of Ae. albopictus contrasted to Ae. aegypti with full susceptibility to pyrethroids except in Kuala Lumpur where moderate resistance is observed. PBO synergist assays suggest metabolic resistance mechanisms play a major role in resistance in both species. Two kdr mutations, F1534C and V1016G, were detected in Ae. aegypti across Malaysia but neither of these mutations were found in Ae. albopictus. Additionally, signatures of selection were detected on the Voltage-gated sodium channel gene in Ae. aegypti but not in Ae. albopictus. The presence of the 1534C allele was significantly associated with pyrethroid resistance and an additive effect to pyrethroid resistance was observed in individuals containing both kdr alleles. Findings from this study will help to design and implement successful insecticide-based interventions against Ae. aegypti and Ae. albopictus to improve dengue control across Malaysia. |
Mendeley readers
The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Madagascar | 2 | <1% |
| Brazil | 1 | <1% |
| Colombia | 1 | <1% |
| United Kingdom | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 297 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 59 | 19% |
| Student > Master | 49 | 16% |
| Researcher | 40 | 13% |
| Student > Ph. D. Student | 36 | 12% |
| Student > Doctoral Student | 20 | 7% |
| Other | 39 | 13% |
| Unknown | 60 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 89 | 29% |
| Biochemistry, Genetics and Molecular Biology | 43 | 14% |
| Environmental Science | 27 | 9% |
| Medicine and Dentistry | 26 | 9% |
| Nursing and Health Professions | 13 | 4% |
| Other | 39 | 13% |
| Unknown | 66 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2021.
All research outputs
#7,489,401
of 22,893,031 outputs
Outputs from Parasites & Vectors
#1,858
of 5,476 outputs
Outputs of similar age
#90,071
of 263,394 outputs
Outputs of similar age from Parasites & Vectors
#26
of 116 outputs
Altmetric has tracked 22,893,031 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,476 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,394 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.