Title |
A logic-based diagram of signalling pathways central to macrophage activation
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Published in |
BMC Systems Biology, April 2008
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DOI | 10.1186/1752-0509-2-36 |
Pubmed ID | |
Authors |
Sobia Raza, Kevin A Robertson, Paul A Lacaze, David Page, Anton J Enright, Peter Ghazal, Tom C Freeman |
Abstract |
The complex yet flexible cellular response to pathogens is orchestrated by the interaction of multiple signalling and metabolic pathways. The molecular regulation of this response has been studied in great detail but comprehensive and unambiguous diagrams describing these events are generally unavailable. Four key signalling cascades triggered early-on in the innate immune response are the toll-like receptor, interferon, NF-kappaB and apoptotic pathways, which co-operate to defend cells against a given pathogen. However, these pathways are commonly viewed as separate entities rather than an integrated network of molecular interactions. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
Spain | 4 | 3% |
United Kingdom | 4 | 3% |
France | 1 | <1% |
India | 1 | <1% |
Russia | 1 | <1% |
Unknown | 109 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 42 | 34% |
Student > Ph. D. Student | 36 | 29% |
Student > Master | 10 | 8% |
Student > Doctoral Student | 6 | 5% |
Professor | 5 | 4% |
Other | 18 | 15% |
Unknown | 7 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 70 | 56% |
Medicine and Dentistry | 14 | 11% |
Biochemistry, Genetics and Molecular Biology | 12 | 10% |
Engineering | 4 | 3% |
Immunology and Microbiology | 4 | 3% |
Other | 11 | 9% |
Unknown | 9 | 7% |