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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action
|
|---|---|
| Published in |
Malaria Journal, March 2013
|
| DOI | 10.1186/1475-2875-12-89 |
| Pubmed ID | |
| Authors |
Gloria NS da Silva, Nicole RG Maria, Desirée C Schuck, Laura N Cruz, Miriam S de Moraes, Myna Nakabashi, Cedric Graebin, Grace Gosmann, Célia RS Garcia, Simone CB Gnoatto |
| Abstract |
The discovery and development of anti-malarial compounds of plant origin and semisynthetic derivatives thereof, such as quinine (QN) and chloroquine (CQ), has highlighted the importance of these compounds in the treatment of malaria. Ursolic acid analogues bearing an acetyl group at C-3 have demonstrated significant anti-malarial activity. With this in mind, two new series of betulinic acid (BA) and ursolic acid (UA) derivatives with ester groups at C-3 were synthesized in an attempt to improve anti-malarial activity, reduce cytotoxicity, and search for new targets. In vitro activity against CQ-sensitive Plasmodium falciparum 3D7 and an evaluation of cytotoxicity in a mammalian cell line (HEK293T) are reported. Furthermore, two possible mechanisms of action of anti-malarial compounds have been evaluated: effects on mitochondrial membrane potential (ΔΨm) and inhibition of β-haematin formation. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Unknown | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 73 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 21% |
| Student > Ph. D. Student | 14 | 19% |
| Student > Bachelor | 8 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Professor > Associate Professor | 4 | 5% |
| Other | 13 | 17% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 20 | 27% |
| Agricultural and Biological Sciences | 16 | 21% |
| Medicine and Dentistry | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 17 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2014.
All research outputs
#13,379,406
of 22,701,287 outputs
Outputs from Malaria Journal
#3,501
of 5,543 outputs
Outputs of similar age
#105,053
of 195,385 outputs
Outputs of similar age from Malaria Journal
#47
of 81 outputs
Altmetric has tracked 22,701,287 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,543 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,385 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.