@RikOssenkoppele @CorriveauNick Oh and the 2022 APOE4 homozygosity together with SORL1 loss of function variants: needs further data (a rare combination) but it appears to have full penetrance as well https://t.co/hqIZqw1Olq
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RT @GJRNicolas: @alzforum @AarhusUni @amsterdamumc I suggest that you have a look at our penetrance paper before claiming this https://t.co…
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Looking upstream in the amyloid forming pathways is of equal, if not greater importance than trying to clear the final product via high risk/little or no benefit mAbs. SORL1 research is on point:
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RT @GJRNicolas: @alzforum @AarhusUni @amsterdamumc I suggest that you have a look at our penetrance paper before claiming this https://t.co…