Title |
Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
|
---|---|
Published in |
Journal of Neuroinflammation, March 2013
|
DOI | 10.1186/1742-2094-10-38 |
Pubmed ID | |
Authors |
Valerio Napolioni, Benjamin Ober-Reynolds, Szabolcs Szelinger, Jason J Corneveaux, Traci Pawlowski, Sharman Ober-Reynolds, Janet Kirwan, Antonio M Persico, Raun D Melmed, David W Craig, Christopher J Smith, Matthew J Huentelman |
Abstract |
Converging lines of evidence point to the existence of immune dysfunction in autism spectrum disorder (ASD), which could directly affect several key neurodevelopmental processes. Previous studies have shown higher cytokine levels in patients with autism compared with matched controls or subjects with other developmental disorders. In the current study, we used plasma-cytokine profiling for 25 discordant sibling pairs to evaluate whether these alterations occur within families with ASD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 84 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 20% |
Student > Master | 14 | 17% |
Student > Bachelor | 12 | 14% |
Student > Ph. D. Student | 8 | 10% |
Student > Doctoral Student | 5 | 6% |
Other | 11 | 13% |
Unknown | 17 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 15% |
Agricultural and Biological Sciences | 10 | 12% |
Biochemistry, Genetics and Molecular Biology | 9 | 11% |
Psychology | 9 | 11% |
Neuroscience | 9 | 11% |
Other | 13 | 15% |
Unknown | 21 | 25% |