Title |
Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
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Published in |
BMC Clinical Pathology, March 2013
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DOI | 10.1186/1472-6890-13-9 |
Pubmed ID | |
Authors |
Sveinung W Sorbye, Thomas K Kilvaer, Andrej Valkov, Tom Donnem, Eivind Smeland, Khalid Al-Shibli, Roy M Bremnes, Lill-Tove Busund |
Abstract |
S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Skp2 has been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers. Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated. |
Mendeley readers
Geographical breakdown
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Norway | 1 | 11% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 33% |
Student > Doctoral Student | 3 | 33% |
Student > Ph. D. Student | 2 | 22% |
Researcher | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 78% |
Biochemistry, Genetics and Molecular Biology | 1 | 11% |
Unknown | 1 | 11% |