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Regulation of blood flow and volume exchange across the microcirculation

Overview of attention for article published in Critical Care, October 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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63 tweeters
facebook
5 Facebook pages
googleplus
1 Google+ user

Citations

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94 Dimensions

Readers on

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242 Mendeley
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Title
Regulation of blood flow and volume exchange across the microcirculation
Published in
Critical Care, October 2016
DOI 10.1186/s13054-016-1485-0
Pubmed ID
Authors

Matthias Jacob, Daniel Chappell, Bernhard F. Becker

Abstract

Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an ingenious oxygen delivery system, comprising steps of convection and diffusion from the upper airways via the lungs and the cardiovascular system to the microvascular area, bridges the gap between oxygen in the outside airspace and the interstitial space around the cells. However, the complexity of this evolutionary development makes us prone to pathophysiological problems. While those problems related to respiration and macrohemodynamics have already been successfully addressed by modern medicine, the pathophysiology of the microcirculation is still often a closed book in daily practice. Nevertheless, here as well, profound physiological understanding is the only key to rational therapeutic decisions. The prime guarantor of tissue oxygenation is tissue blood flow. Therefore, on the premise of intact macrohemodynamics, the microcirculation has three major responsibilities: 1) providing access for oxygenated blood to the tissues and appropriate return of volume; 2) maintaining global tissue flood flow, even in the face of changes in central blood pressure; and 3) linking local blood flow to local metabolic needs. It is an intriguing concept of nature to do this mainly by local regulatory mechanisms, impacting primarily on flow resistance, be this via endothelial or direct smooth muscle actions. The final goal of microvascular blood flow per unit of time is to ensure the needed exchange of substances between tissue and blood compartments. The two principle means of accomplishing this are diffusion and filtration. While simple diffusion is the quantitatively most important form of capillary exchange activity for the respiratory gases, water flux across the blood-brain barrier is facilitated via preformed specialized channels, the aquaporines. Beyond that, the vascular barrier is practically nowhere completely tight for water, with paracellular filtration giving rise to generally low but permanent fluid flux outwards into the interstitial space at the microvascular high pressure segment. At the more leaky venular aspect, both filtration and diffusion allow for bidirectional passage of water, nutrients, and waste products. We are just beginning to appreciate that a major factor for maintaining tissue fluid homeostasis appears to be the integrity of the endothelial glycocalyx.

Twitter Demographics

The data shown below were collected from the profiles of 63 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 242 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 2 <1%
Sweden 1 <1%
Canada 1 <1%
Mexico 1 <1%
United States 1 <1%
Unknown 236 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 40 17%
Researcher 26 11%
Student > Ph. D. Student 26 11%
Student > Bachelor 25 10%
Student > Postgraduate 22 9%
Other 59 24%
Unknown 44 18%
Readers by discipline Count As %
Medicine and Dentistry 119 49%
Engineering 14 6%
Agricultural and Biological Sciences 11 5%
Biochemistry, Genetics and Molecular Biology 9 4%
Neuroscience 9 4%
Other 33 14%
Unknown 47 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2021.
All research outputs
#803,313
of 21,753,060 outputs
Outputs from Critical Care
#631
of 5,873 outputs
Outputs of similar age
#18,317
of 316,720 outputs
Outputs of similar age from Critical Care
#68
of 272 outputs
Altmetric has tracked 21,753,060 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,873 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.