Title |
Transcriptional effects of 1,25 dihydroxyvitamin D3physiological and supra-physiological concentrations in breast cancer organotypic culture
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Published in |
BMC Cancer, March 2013
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DOI | 10.1186/1471-2407-13-119 |
Pubmed ID | |
Authors |
Cintia Milani, Maria Lucia Hirata Katayama, Eduardo Carneiro de Lyra, JoEllen Welsh, Laura Tojeiro Campos, M Mitzi Brentani, Maria do Socorro Maciel, Rosimeire Aparecida Roela, Paulo Roberto del Valle, João Carlos Guedes Sampaio Góes, Suely Nonogaki, Rodrigo Esaki Tamura, Maria Aparecida Azevedo Koike Folgueira |
Abstract |
Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH)(2)D(3) (50-100nM). Our aim was to evaluate the transcriptional effects of 1,25(OH)(2)D(3) in a more physiological model of breast cancer, consisting of fresh tumor slices exposed to 1,25(OH)(2)D(3) at concentrations that can be attained in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Hong Kong | 1 | 2% |
United States | 1 | 2% |
Unknown | 46 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 15% |
Student > Bachelor | 7 | 15% |
Researcher | 6 | 13% |
Student > Ph. D. Student | 5 | 10% |
Other | 4 | 8% |
Other | 11 | 23% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 21% |
Medicine and Dentistry | 8 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
Unspecified | 2 | 4% |
Other | 9 | 19% |
Unknown | 8 | 17% |