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Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson’s disease

Overview of attention for article published in Journal of NeuroEngineering and Rehabilitation, October 2016
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Title
Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson’s disease
Published in
Journal of NeuroEngineering and Rehabilitation, October 2016
DOI 10.1186/s12984-016-0205-y
Pubmed ID
Authors

Gian Pal, Joan O’Keefe, Erin Robertson-Dick, Bryan Bernard, Sharlet Anderson, Deborah Hall

Abstract

Our primary objective was to determine the relationship between global cognitive function and specific domains of gait and balance in a cohort of Parkinson's disease (PD) subjects. In a secondary analysis, we determined whether specific cognitive domains correlated with gait and balance performance. Fourteen PD subjects (mean age 61.1 ± 7.8 years) were recruited from the Rush University Medical Center Movement Disorders clinic. Subjects underwent clinical assessment using the motor subsection of the Unified Parkinson's Disease Rating Scale (UPDRS) followed by quantitative gait and balance assessments using the APDM Mobility Lab™ system (Mobility Lab, APDM Inc., Portland, OR). Subjects completed global cognitive testing using the Mattis Dementia Rating Scale (MDRS) as well as domain specific cognitive measures. Spearman's rho was used to assess correlations between cognitive measures and gait and balance function, with False Discovery Rate (FDR) correction for multiple comparisons. Global cognitive function had the strongest correlation with stride velocity (r = 0.816, p = 0.001), turn duration (r = -0.806, p = 0.001), number of steps to turn (r = -0.830, p = 0.001), and mean velocity of postural sway in the medio-lateral direction (r = -0.726, p = 0.005). A significant correlation was found between processing speed and two turning measures (turn duration, r = -0.884, p = 0.001; number of steps to turn, r = -0.954, p < 0.001), but no other associations were found between specific cognitive domains and gait domains. This pilot study provides preliminary data regarding the association between global cognitive function and pace-related measures of gait, turning, and postural sway. Furthermore, reduced processing speed was found to be associated with difficulty in performing turns.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 124 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 15%
Student > Master 18 15%
Student > Doctoral Student 15 12%
Researcher 14 11%
Student > Bachelor 14 11%
Other 15 12%
Unknown 30 24%
Readers by discipline Count As %
Medicine and Dentistry 19 15%
Neuroscience 18 15%
Nursing and Health Professions 12 10%
Psychology 11 9%
Engineering 11 9%
Other 21 17%
Unknown 32 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#17,823,285
of 22,896,955 outputs
Outputs from Journal of NeuroEngineering and Rehabilitation
#940
of 1,285 outputs
Outputs of similar age
#223,650
of 313,742 outputs
Outputs of similar age from Journal of NeuroEngineering and Rehabilitation
#8
of 11 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,285 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.