Title |
Mast cells and the liver aging process
|
---|---|
Published in |
Immunity & Ageing, March 2013
|
DOI | 10.1186/1742-4933-10-9 |
Pubmed ID | |
Authors |
Fabio Grizzi, Giuseppe Di Caro, Luigi Laghi, Paul Hermonat, Paolo Mazzola, Diane D Nguyen, Saba Radhi, Jose A Figueroa, Everardo Cobos, Giorgio Annoni, Maurizio Chiriva-Internati |
Abstract |
It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism ability to adjust to metabolic, infectious, and immunologic insults. Although liver tests are not significantly affected by age, the presentation of liver diseases such as viral hepatitis may be subtler in the elderly population than that of younger patients.Human immunosenescence is a situation in which the immune system, particularly T lymphocyte function, deteriorates with age, while innate immunity is negligibly affected and in some cases almost up-regulated.We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 1% |
Germany | 1 | 1% |
France | 1 | 1% |
Unknown | 75 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 18% |
Researcher | 12 | 15% |
Student > Bachelor | 10 | 13% |
Student > Ph. D. Student | 8 | 10% |
Other | 7 | 9% |
Other | 12 | 15% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 31% |
Agricultural and Biological Sciences | 11 | 14% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Immunology and Microbiology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 7 | 9% |
Unknown | 17 | 22% |