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X Demographics
Mendeley readers
| Title |
Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family
|
|---|---|
| Published in |
BMC Biology, May 2010
|
| DOI | 10.1186/1741-7007-8-70 |
| Pubmed ID | |
| Authors |
Daniel H Haft, Malay Kumar Basu, Douglas A Mitchell |
| Abstract |
A new family of natural products has been described in which cysteine, serine and threonine from ribosomally-produced peptides are converted to thiazoles, oxazoles and methyloxazoles, respectively. These metabolites and their biosynthetic gene clusters are now referred to as thiazole/oxazole-modified microcins (TOMM). As exemplified by microcin B17 and streptolysin S, TOMM precursors contain an N-terminal leader sequence and C-terminal core peptide. The leader sequence contains binding sites for the posttranslational modifying enzymes which subsequently act upon the core peptide. TOMM peptides are small and highly variable, frequently missed by gene-finders and occasionally situated far from the thiazole/oxazole forming genes. Thus, locating a substrate for a particular TOMM pathway can be a challenging endeavor. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 158 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 34 | 21% |
| Student > Ph. D. Student | 33 | 20% |
| Student > Master | 26 | 16% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 7 | 4% |
| Other | 24 | 15% |
| Unknown | 21 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 36% |
| Biochemistry, Genetics and Molecular Biology | 36 | 22% |
| Chemistry | 30 | 18% |
| Immunology and Microbiology | 4 | 2% |
| Environmental Science | 3 | 2% |
| Other | 9 | 6% |
| Unknown | 22 | 13% |