Title |
Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains
|
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Published in |
BMC Neuroscience, March 2013
|
DOI | 10.1186/1471-2202-14-40 |
Pubmed ID | |
Authors |
Cécile Moro, Napoleon Torres, Nabil El Massri, David Ratel, Daniel M Johnstone, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid |
Abstract |
We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Balb/c albino mice, a well-known model for Parkinson's disease. The present study explores whether NIr treatment offers neuroprotection to these cells in C57BL/6 pigmented mice. In addition, we examine whether NIr influences behavioural activity in both strains after MPTP treatment. We tested for various locomotive parameters in an open-field test, namely velocity, high mobility and immobility. |
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