Title |
Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
|
---|---|
Published in |
Journal of Hematology & Oncology, March 2013
|
DOI | 10.1186/1756-8722-6-22 |
Pubmed ID | |
Authors |
Yiying Wang, Yue Wang, Jie Li, Janiel Cragun, Kenneth Hatch, Setsuko K Chambers, Wenxin Zheng |
Abstract |
Lynch syndrome (LS), an autosomal dominant inherited cancer susceptibility syndrome, also known as hereditary non-polyposis colon cancer (HNPCC), is caused by a germline mutation in one of several DNA mismatch repair (MMR) genes. LS is the most common presentation of hereditary colorectal cancer (CRC), accounting for about 2-5% of all CRC cases. More recently, it is found that a similar number of endometrial cancers is also due to one of the MMR gene mutations. There has been significant progress in LS-related CRC in terms of molecular pathogenesis, risks, genetic basis, and cancer prevention. In contrast, the advance about LS-related endometrial cancer (EC) is very much limited. In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 1% |
Brazil | 1 | 1% |
Egypt | 1 | 1% |
Unknown | 90 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 10 | 11% |
Student > Ph. D. Student | 10 | 11% |
Researcher | 10 | 11% |
Student > Master | 10 | 11% |
Student > Bachelor | 8 | 9% |
Other | 22 | 24% |
Unknown | 23 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 38 | 41% |
Agricultural and Biological Sciences | 13 | 14% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Nursing and Health Professions | 4 | 4% |
Unspecified | 1 | 1% |
Other | 0 | 0% |
Unknown | 29 | 31% |