北京基因组所等鉴定出尿路上皮癌中具有预后分层的DNA甲基化亚型
Chinese Academy of Science,
尿路上皮癌(UC)是泌尿生殖系统常见的恶性肿瘤之一,包含上尿路上皮癌和膀胱癌,均起源于尿路上皮细胞,但上尿路上皮癌恶性程度更高,诊断时约60%的患者已发生肌层浸润,而膀胱癌患者发生肌层浸润的比例仅15-25%。越来越多的证据表明,DNA甲基化与肿瘤的进展紧密…
尿路上皮癌(UC)是泌尿生殖系统常见的恶性肿瘤之一,包含上尿路上皮癌和膀胱癌,均起源于尿路上皮细胞,但上尿路上皮癌恶性程度更高,诊断时约60%的患者已发生肌层浸润,而膀胱癌患者发生肌层浸润的比例仅15-25%。越来越多的证据表明,DNA甲基化与肿瘤的进展紧密…
Guadecitabine (SGI-110), a DNA methyltransferase inhibitor, showed therapeutic effects in T24 and UMUC-3 cells.
Guadecitabine (SGI-110), a DNA methyltransferase inhibitor, showed therapeutic effects in T24 and UMUC-3 cells.
Urothelial carcinoma (UC) is one of the most common malignancies genitourinary cancers, including upper tract urothelial…