Title |
The Qure study: Q fever fatigue syndrome – response to treatment; a randomized placebo-controlled trial
|
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Published in |
BMC Infectious Diseases, March 2013
|
DOI | 10.1186/1471-2334-13-157 |
Pubmed ID | |
Authors |
Stephan P Keijmel, Corine E Delsing, Tom Sprong, Gijs Bleijenberg, Jos WM van der Meer, Hans Knoop, Chantal P Bleeker-Rovers |
Abstract |
Q fever is a zoonosis that is present in many countries. Q fever fatigue syndrome (QFS) is one of the most frequent sequelae after an acute Q fever infection. QFS is characterized by persistent fatigue following an acute Q fever infection, leading to substantial morbidity and a high socio-economic burden. The occurrence of QFS is well-documented, and has been described in many countries over the past decades. However, a treatment with proven efficacy is not available. Only a few uncontrolled studies have tested the efficacy of treatment with antibiotics on QFS. These studies suggest a positive effect of long-term treatment with a tetracycline on performance state; however, no randomized controlled trials have been performed. Cognitive behavioral therapy (CBT) has been proven to be an effective treatment modality for chronic fatigue in other diseases, but has not yet been tested in QFS. Therefore, we designed a trial to assess the efficacy of long-term treatment with the tetracycline doxycycline and CBT in patients with QFS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 13% |
Netherlands | 1 | 13% |
Belgium | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 85 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 15% |
Researcher | 12 | 14% |
Student > Master | 10 | 12% |
Student > Ph. D. Student | 9 | 10% |
Student > Postgraduate | 5 | 6% |
Other | 11 | 13% |
Unknown | 26 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 26% |
Psychology | 8 | 9% |
Nursing and Health Professions | 6 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 13 | 15% |
Unknown | 29 | 34% |