Title |
Resveratrol represses YKL-40 expression in human glioma U87 cells
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Published in |
BMC Cancer, October 2010
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DOI | 10.1186/1471-2407-10-593 |
Pubmed ID | |
Authors |
Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei, Takashi Tamiya |
Abstract |
Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with tumour burden in addition to being an independent prognostic factor of a short relapse-free interval as well as short overall survival in patients with various cancers. Our previous study revealed that YKL-40 was closely correlated with the pathological grades of human primary astrocytomas and played a crucial role in glioma cell proliferation. Hence, YKL-40 could be an attractive target in the design of anti-cancer therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
United States | 1 | 2% |
Ukraine | 1 | 2% |
Germany | 1 | 2% |
Unknown | 55 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 24% |
Researcher | 12 | 20% |
Professor | 6 | 10% |
Student > Bachelor | 5 | 8% |
Student > Master | 5 | 8% |
Other | 11 | 19% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 34% |
Agricultural and Biological Sciences | 16 | 27% |
Biochemistry, Genetics and Molecular Biology | 8 | 14% |
Neuroscience | 2 | 3% |
Sports and Recreations | 1 | 2% |
Other | 3 | 5% |
Unknown | 9 | 15% |