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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human single-stranded DNA binding proteins are essential for maintaining genomic stability
|
|---|---|
| Published in |
BMC Molecular and Cell Biology, April 2013
|
| DOI | 10.1186/1471-2199-14-9 |
| Pubmed ID | |
| Authors |
Nicholas W Ashton, Emma Bolderson, Liza Cubeddu, Kenneth J O’Byrne, Derek J Richard |
| Abstract |
The double-stranded conformation of cellular DNA is a central aspect of DNA stabilisation and protection. The helix preserves the genetic code against chemical and enzymatic degradation, metabolic activation, and formation of secondary structures. However, there are various instances where single-stranded DNA is exposed, such as during replication or transcription, in the synthesis of chromosome ends, and following DNA damage. In these instances, single-stranded DNA binding proteins are essential for the sequestration and processing of single-stranded DNA. In order to bind single-stranded DNA, these proteins utilise a characteristic and evolutionary conserved single-stranded DNA-binding domain, the oligonucleotide/oligosaccharide-binding (OB)-fold. In the current review we discuss a subset of these proteins involved in the direct maintenance of genomic stability, an important cellular process in the conservation of cellular viability and prevention of malignant transformation. We discuss the central roles of single-stranded DNA binding proteins from the OB-fold domain family in DNA replication, the restart of stalled replication forks, DNA damage repair, cell cycle-checkpoint activation, and telomere maintenance. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 1% |
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Unknown | 131 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 26% |
| Student > Master | 21 | 15% |
| Researcher | 18 | 13% |
| Student > Bachelor | 15 | 11% |
| Student > Doctoral Student | 6 | 4% |
| Other | 13 | 10% |
| Unknown | 28 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 28% |
| Biochemistry, Genetics and Molecular Biology | 36 | 26% |
| Medicine and Dentistry | 11 | 8% |
| Chemistry | 7 | 5% |
| Computer Science | 2 | 1% |
| Other | 11 | 8% |
| Unknown | 31 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2020.
All research outputs
#4,659,159
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#106
of 1,233 outputs
Outputs of similar age
#37,925
of 212,987 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#4
of 23 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.