Title |
Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
|
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Published in |
BMC Medicine, April 2013
|
DOI | 10.1186/1741-7015-11-99 |
Pubmed ID | |
Authors |
Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi, Josette Cadusseau |
Abstract |
Long-term biodistribution of nanomaterials used in medicine is largely unknown. This is the case for alum, the most widely used vaccine adjuvant, which is a nanocrystalline compound spontaneously forming micron/submicron-sized agglomerates. Although generally well tolerated, alum is occasionally detected within monocyte-lineage cells long after immunization in presumably susceptible individuals with systemic/neurologic manifestations or autoimmune (inflammatory) syndrome induced by adjuvants (ASIA). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 106 | 22% |
United Kingdom | 13 | 3% |
Canada | 11 | 2% |
France | 7 | 1% |
Japan | 4 | <1% |
Australia | 4 | <1% |
Comoros | 3 | <1% |
Italy | 3 | <1% |
India | 2 | <1% |
Other | 22 | 5% |
Unknown | 307 | 64% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 434 | 90% |
Practitioners (doctors, other healthcare professionals) | 30 | 6% |
Scientists | 10 | 2% |
Science communicators (journalists, bloggers, editors) | 7 | 1% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
France | 1 | 1% |
Belgium | 1 | 1% |
Australia | 1 | 1% |
Unknown | 91 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 20 | 21% |
Student > Ph. D. Student | 17 | 18% |
Other | 10 | 11% |
Student > Master | 9 | 9% |
Student > Doctoral Student | 8 | 8% |
Other | 15 | 16% |
Unknown | 16 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 28% |
Agricultural and Biological Sciences | 17 | 18% |
Immunology and Microbiology | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Nursing and Health Professions | 3 | 3% |
Other | 16 | 17% |
Unknown | 18 | 19% |