Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia

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RT @GenomeBiology: Analysis of single-cell HiC in leukemia from @zhihao_xing, Chen, Shlien, Wen & co. Genes creating fusions tend to be clo…

10 Aug 2022

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Analysis of single-cell HiC in leukemia from @zhihao_xing, Chen, Shlien, Wen & co. Genes creating fusions tend to be close in space. Many are targets of RUNX1, suggesting localization in transcription factories. Knockdown of RUNX1 reduces contacts. htt

10 Aug 2022

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